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Article

Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function

23 Apr 2011

Abstract excerpt

Alveolar barrier function depends critically on the claudin family tight junction proteins. Of the major claudins expressed by alveolar epithelial cells, claudin (Cldn)-3 and Cldn-4 are the most closely related by amino acid homology, yet they differ dramatically in the pattern of expression. Previously published reports have shown that Cldn-3 is predominantly expressed by type II alveolar epithelial cells;...

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PMID: 21515662
DOI: 10.1152/ajplung.00299.2010

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