Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

doi:10.1172/JCI90429

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Article

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

The Journal of clinical investigation - 1 Mar 2018

Zhou Beiyun, Flodby Per, Luo Jiao, Castillo Dan R, Liu Yixin, Yu Fa-Xing, McConnell Alicia, Varghese Bino, Li Guanglei, Chimge Nyam-Osor, Sunohara Mitsuhiro, Koss Michael N, Elatre Wafaa, Conti Peter, Liebler Janice M, Yang Chenchen, Marconett Crystal N, Laird-Offringa Ite A, Minoo Parviz, Guan Kunliang, Stripp Barry R, Crandall Edward D, Borok Zea

Abstract excerpt

Claudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic progression is unclear. Here, we demonstrated that knockout of Cldn18, a claudin family member highly expressed in lung alveolar epithelium, leads to lung enlargement, parenchymal expansion, increased abundance and proliferation of...

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Identifiers

PMID: 29400695
DOI: 10.1172/JCI90429
PMCID: PMC5824875

Genes

CLDN18
LATS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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