Article
Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.
American journal of respiratory cell and molecular biology - 1 Aug 2014
Li Guanglei, Flodby Per, Luo Jiao, Kage Hidenori, Sipos Arnold, Gao Danping, Ji Yanbin, Beard LaMonta L, Marconett Crystal N, DeMaio Lucas, Kim Yong Ho, Kim Kwang-Jin, Laird-Offringa Ite A, Minoo Parviz, Liebler Janice M, Zhou Beiyun, Crandall Edward D, Borok Zea
Abstract excerpt
Claudin proteins are major constituents of epithelial and endothelial tight junctions (TJs) that regulate paracellular permeability to ions and solutes. Claudin 18, a member of the large claudin family, is highly expressed in lung alveolar epithelium. To elucidate the role of claudin 18 in alveolar epithelial barrier function, we generated claudin 18 knockout (C18 KO) mice. C18 KO mice exhibited increased solute...
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