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Article

Mislocalization of BRCA1-complex due to ABRAXAS Arg361Gln mutation.

Journal of biomolecular structure & dynamics - 1 Jan 2015

Vikrant, Kumar Rajan, Siddiqui Quadir, Singh Nalini, Waghmare Sanjeev K, Varma Ashok K

Abstract excerpt

ABRAXAS is an integral member of BRCA1-complex, which helps in its recruitment to the DNA damage site. It interacts with BRCA1 via its C-terminal phospho-peptide binding motif while the N-terminal associates with RAP80, and thereby recruits the BRCA1-complex at the site of DNA damage. Nonetheless, how ABRAXAS helps in the structural integrity of BRCA1-complex, and its DNA repair mechanism remains elusive. To...

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Source

Identifiers

PMID: 25105795
DOI: 10.1080/07391102.2014.945484

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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