Article
ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.
PloS one - 1 Jan 2016
Renault Anne-Laure, Lesueur Fabienne, Coulombe Yan, Gobeil Stéphane, Soucy Penny, Hamdi Yosr, Desjardins Sylvie, Le Calvez-Kelm Florence, Vallée Maxime, Voegele Catherine, Hopper John L, Andrulis Irene L, Southey Melissa C, John Esther M, Masson Jean-Yves, Tavtigian Sean V, Simard Jacques
Abstract excerpt
Approximately half of the familial aggregation of breast cancer remains unexplained. This proportion is less for early-onset disease where familial aggregation is greater, suggesting that other susceptibility genes remain to be discovered. The majority of known breast cancer susceptibility genes are involved in the DNA double-strand break repair pathway. ABRAXAS is involved in this pathway and mutations in this...
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