Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional implication of RAP80 ΔGlu81 mutation.

PloS one - 1 Jan 2013

Vikrant, Kumar Rajan, Yadav Lumbini R, Nakhwa Pallavi, Waghmare Sanjeev K, Goyal Peyush, Varma Ashok K

Abstract excerpt

Receptor Associated Protein 80 (RAP80) is a member of RAP80-BRCA1-CCDC98 complex family and helps in its recruitment to the DNA damage site for effective homologous recombination repair. It encompasses two tandem UIMs (UIM1 and UIM2) motif at its N-terminus, which interact with K-63 linked polyubiquitin chain(s) on H2AX and thereby assemble the RAP80-BRCA1 complex at the damage site. Nevertheless, how RAP80 helps...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Histone Chaperones
Share to Molecular Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Interaction Domains and Motifs

Share to Protein Stability

Share to Proteolysis

Share to Recombinant Proteins

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 24039796
DOI: 10.1371/journal.pone.0072707
PMCID: PMC3767628

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional implication of RAP80 ΔGlu81 mutation.PMID 24039796Read ↗

Molecular basis for impaired DNA damage response function associated with the RAP80 ΔE81 defect.Semantic proximity Read ↗

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.Semantic proximity Read ↗

The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair ResponseSemantic proximity Read ↗

Mislocalization of BRCA1-complex due to ABRAXAS Arg361Gln mutation.Semantic proximity Read ↗

LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesisSemantic proximity Read ↗

Structural and functional characterization of the MERIT40 to understand its role in DNA repair.Semantic proximity Read ↗

The Ku70-binding site of Ku80 is required for the stabilization of Ku70 in the cytoplasm, for the nuclear translocation of Ku80, and for Ku80-dependent DNA repair.Semantic proximity Read ↗

Germline RAP80 mutations and susceptibility to breast cancer.Semantic proximity Read ↗

[DNA Repair Function and Mutation of an H2B Monoubiquitination Factor WDR70 in Ovarian Cancer].Semantic proximity Read ↗

Characterization of a carboxy-terminal BRCA1 interacting proteinSemantic proximity Read ↗

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repairSemantic proximity Read ↗

A fragmented alignment method detects a putative phosphorylation site and a putative BRC repeat in the Drosophila melanogaster BRCA2 proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.