Article
Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.
Science translational medicine - 22 Feb 2012
Solyom Szilvia, Aressy Bernadette, Pylkäs Katri, Patterson-Fortin Jeffrey, Hartikainen Jaana M, Kallioniemi Anne, Kauppila Saila, Nikkilä Jenni, Kosma Veli-Matti, Mannermaa Arto, Greenberg Roger A, Winqvist Robert
Abstract excerpt
Breast cancer is the most common cancer in women in developed countries and has a well-established genetic component. Germline mutations in a network of genes encoding BRCA1, BRCA2, and their interacting partners confer hereditary susceptibility to breast cancer. Abraxas directly interacts with the BRCA1 BRCT (BRCA1 carboxyl-terminal) repeats and contributes to BRCA1-dependent DNA damage responses, making Abraxas...
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