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Extending the Potency and Lifespan of Antibiotics: Inhibitors of Gram-Negative Bacterial Efflux Pumps

25 Apr 2024

Abstract excerpt

Efflux is a natural process found in all prokaryotic and eukaryotic cells that removes a diverse range of substrates from inside to outside. Many antibiotics are substrates of bacterial efflux pumps, and modifications to the structure or overexpression of efflux pumps are an important resistance mechanism utilized by many multidrug-resistant bacteria. Therefore, chemical inhibition of bacterial efflux to...

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Share to Antibiotic Resistance in Bacteria
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Share to Pneumonia and Respiratory Infections

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PMID: 38661541
DOI: 10.1021/acsinfecdis.4c00091

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