Article
Molecular heterogeneity of familial myeloproliferative neoplasms revealed by analysis of the commonly acquired JAK2, CALR and MPL mutations.
Familial cancer - 1 Dec 2014
Langabeer Stephen E, Haslam Karl, Linders Jennifer, Percy Melanie J, Conneally Eibhlin, Hayat Amjad, Hennessy Brian, Leahy Maeve, Murphy Karen, Murray Margaret, Ni Ainle Fionnuala, Thornton Patrick, Sargent Jeremy
Abstract excerpt
The myeloproliferative neoplasms (MPN) are clonal, hematological malignancies that include polycythemia vera, essential thrombocythemia and primary myelofibrosis. While most cases of MPN are sporadic in nature, a familial pattern of inheritance is well recognised. The phenotype and status of the commonly acquired JAK2 V617F, CALR exon 9 and MPL W515L/K mutations in affected individuals from a consecutive series...
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