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Article

Primary myelofibrosis with concurrent MPL and atypical JAK2 mutations.

Journal of hematopathology - 4 Jun 2025

Barua Subit, Randall Cara, Howell David, Torres Gustavo, Sasi Ramakrishnan, Bhagavathi Sharathkumar, Perrotta Peter L

Abstract excerpt

Distinct bone marrow morphology is considered the primary basis for the diagnosis of BCR::ABL1-negative myeloproliferative neoplasms (MPNs). However, presence of a mutually exclusive classical driver mutation in JAK2, CALR, or MPL aids in diagnosing and determining the prognosis of polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Few recent studies have reported presence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40467885
DOI: 10.1007/s12308-025-00642-w

Genes

JAK2
MPL
ABL1
ASXL1
BCR
CALR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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