Article
Novel modes of MPL activation in triple-negative myeloproliferative neoplasms.
Pathology - 1 Feb 2023
Samaraweera Saumya E, Geukens Tatjana, Casolari Debora A, Nguyen Tran, Sun Caitlyn, Bailey Sheree, Moore Sarah, Feng Jinghua, Schreiber Andreas W, Parker Wendy T, Brown Anna L, Butcher Carolyn, Bardy Peter G, Osborn Michael, Scott Hamish S, Talaulikar Dipti, Grove Carolyn S, Hahn Christopher N, D'Andrea Richard J, Ross David M
Abstract excerpt
The identification of a somatic mutation associated with myeloid malignancy is of diagnostic importance in myeloproliferative neoplasms (MPNs). Individuals with no mutation detected in common screening tests for variants in JAK2, CALR, and MPL are described as 'triple-negative' and pose a diagnostic challenge if there is no other evidence of a clonal disorder. To identify potential drivers that might explain the...
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