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Article

Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-3.

Scientific reports - 8 Aug 2014

Homma Takujiro, Ishibashi Daisuke, Nakagaki Takehiro, Fuse Takayuki, Sano Kazunori, Satoh Katsuya, Atarashi Ryuichiro, Nishida Noriyuki

Abstract excerpt

As a prompt response against invasion of various viruses, interferon regulatory factor-3 (IRF-3) is initially phosphorylated to become activated and upregulates mainly Type I Interferons (IFN-I) in most cell types. We previously reported that IRF-3-dependent host innate immune responses partially interfere in infection of prions. Here, we found that stable infection of prion suppressed IRF-3 gene-expression. The...

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Identifiers

PMID: 25103253
DOI: 10.1038/srep06006
PMCID: PMC4126003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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