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Article

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch.

The Journal of biological chemistry - 3 Aug 2007

Panne Daniel, McWhirter Sarah M, Maniatis Tom, Harrison Stephen C

Abstract excerpt

The transcription factor interferon regulatory factor 3 (IRF-3) regulates genes in the innate immune response. IRF-3 is activated through phosphorylation by the kinases IKK epsilon and/or TBK1. Phosphorylation results in IRF-3 dimerization and removal of an autoinhibitory structure to allow inter...

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Source

Identifiers

PMID: 17526488
DOI: 10.1074/jbc.M703019200

Genes

TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17526488-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch.PMID 17526488Read ↗

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