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Article

Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children.

The American journal of clinical nutrition - 1 Jan 2010

Cole Shelley A, Butte Nancy F, Voruganti V Saroja, Cai Guowen, Haack Karin, Kent Jack W, Blangero John, Comuzzie Anthony G, McPherson John D, Gibbs Richard A

Abstract excerpt

BACKGROUND: Melanocortin-4-receptor (MC4R) haploinsufficiency is the most common form of monogenic obesity; however, the frequency of MC4R variants and their functional effects in general populations remain uncertain. OBJECTIVE: The aim was to identify and characterize the effects of MC4R variants in Hispanic children. DESIGN: MC4R was resequenced in 376 parents, and the identified single nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19889825
DOI: 10.3945/ajcn.2009.28514
PMCID: PMC2793108

Genes

MGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children.PMID 19889825Read ↗

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.Semantic proximity Read ↗

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Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity.Semantic proximity Read ↗

Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/near MC4R Gene with Obesity-Related Biomarkers in a Spanish Pediatric CohortSemantic proximity Read ↗

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The genetic epidemiology of melanocortin 4 receptor variants.Semantic proximity Read ↗

Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort.Semantic proximity Read ↗

Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants.Semantic proximity Read ↗

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