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Article

Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians.

Diabetes - 1 Oct 2004

Ma Lijun, Tataranni P Antonio, Bogardus Clifton, Baier Leslie J

Abstract excerpt

Heterozygous coding mutations in the melanocortin 4 receptor gene (MC4R) are the most common genetic causes of severe human obesity identified to date. To determine whether MC4R has a role in causing severe obesity in Pima Indians, we sequenced the coding region of this gene in 426 full-heritage, non-first-degree related, adult Pima Indians (300 severely obese and 126 nondiabetic nonobese control subjects). Three...

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Identifiers

PMID: 15448103
DOI: 10.2337/diabetes.53.10.2696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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