Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy.

Journal of molecular and cellular cardiology - 1 Jan 2015

Kim Eun Young, Zhang Yi, Beketaev Ilimbek, Segura Ana Maria, Yu Wei, Xi Yutao, Chang Jiang, Wang Jun

Abstract excerpt

Cardiomyopathy presents a major health issue and is a leading cause of heart failure. Although a subset of familial cardiomyopathy is associated with genetic mutations, over 50% of cardiomyopathy is defined as idiopathic, the mechanisms underlying which are under intensive investigation. SUMO conjugation is a dynamic posttranslational modification that can be readily reversed by the activity of sentrin-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathies
Share to Cysteine Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dynamins

Share to Heart Failure

Share to Mitochondria, Heart

Share to Myocytes, Cardiac

Share to Peptide Hydrolases

Share to Sumoylation

Source

Identifiers

PMID: 25128087
DOI: 10.1016/j.yjmcc.2014.08.003

Genes

SENP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy.PMID 25128087Read ↗

Cardiomyocytes Deficiency of SENP1 Promotes Myocardial Fibrosis via Paracrine ActionSemantic proximity Read ↗

UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised HeartsSemantic proximity Read ↗

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes.Semantic proximity Read ↗

A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia.Semantic proximity Read ↗

SUMO--a post-translational modification with therapeutic potential?Semantic proximity Read ↗

Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation.Semantic proximity Read ↗

Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction.Semantic proximity Read ↗

Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagySemantic proximity Read ↗

Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesisSemantic proximity Read ↗

Neddylation Regulates Mitochondrial Dynamics and Turnover in the Adult HeartSemantic proximity Read ↗

Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent MitophagySemantic proximity Read ↗

ALKBH5 mediated RNA N6-methyladenosine demethylation protects against myocardial I/R induced injury via FSP1 dependent inhibition of ferroptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.