Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Common Pathogenic Mechanism Linking Type-2 Diabetes and Alzheimer's Disease: Evidence from Animal Models

1 Jan 2011

Abstract excerpt

The failure of large-scale drug trials targeting the amyloidogenic pathway in Alzheimer's disease (AD) is increasing the need to identify a novel pathogenic mechanism. Studies finding a relationship between sporadic AD and type-2 diabetes mellitus (T2DM) are now receiving more attention. The risk for developing both T2DM and sporadic AD increases exponentially with age, and having T2DM doubles the risk of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Natural Antidiabetic Agents Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21519521
DOI: 10.3988/jcn.2011.7.1.10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Common Pathogenic Mechanism Linking Type-2 Diabetes and Alzheimer's Disease: Evidence from Animal ModelsPMID 21519521Read ↗

Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: Common Molecular Mechanism and Therapeutic TargetsSemantic proximity Read ↗

Alzheimer’s Disease and Type 2 Diabetes Relationships. I. Cellular and Molecular Common Pathological MechanismsSemantic proximity Read ↗

Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular DamagesSemantic proximity Read ↗

Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal modelsSemantic proximity Read ↗

Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and InsulinSemantic proximity Read ↗

Streptozotocin mechanisms and its role in rodent models for Alzheimer’s diseaseSemantic proximity Read ↗

Insulin dysfunction and Tau pathologySemantic proximity Read ↗

Exploring the interplay of glucose metabolism, insulin resistance, and neurodegenerative pathologies: insights from streptozotocin and hypoglycaemic in vitro modelsSemantic proximity Read ↗

Insulin Resistance and Diabetes Mellitus in Alzheimer’s DiseaseSemantic proximity Read ↗

Alzheimer’s Disease and Diabetes: Insulin Signaling as the Bridge Linking Two PathologiesSemantic proximity Read ↗

Increased Aβ production prompts the onset of glucose intolerance and insulin resistance.Semantic proximity Read ↗

Diabetes and Parkinson’s Disease: Understanding Shared Molecular MechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.