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Article

Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease.

PloS one - 19 Nov 2009

Ke Yazi D, Delerue Fabien, Gladbach Amadeus, Götz Jürgen, Ittner Lars M

Abstract excerpt

Diabetes mellitus (DM) is characterized by hyperglycemia caused by a lack of insulin, insulin resistance, or both. There is increasing evidence that insulin also plays a role in Alzheimer's disease (AD) as it is involved in the metabolism of beta-amyloid (Abeta) and tau, two proteins that form Abeta plaques and neurofibrillary tangles (NFTs), respectively, the hallmark lesions in AD. Here, we examined the effects...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19936237
DOI: 10.1371/journal.pone.0007917
PMCID: PMC2775636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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