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Article

Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice

1 Jan 2014

Abstract excerpt

Major depression disorder (MDD) or depression is highly prevalent in individuals with diabetes, and the depressive symptoms are more severe and less responsive to antidepressant therapies in these patients. The underlying mechanism is little understood. We hypothesized that the pathophysiology of comorbid depression was more complex than that proposed for MDD and that neural cell death played a role in the...

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PMID: 24764190
DOI: 10.1242/dmm.016162

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