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Article

EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.

Cancer genetics - 1 Jun 2012

Beck Robert, Monument Michael J, Watkins W Scott, Smith Richard, Boucher Kenneth M, Schiffman Joshua D, Jorde Lynn B, Randall R Lor, Lessnick Stephen L

Abstract excerpt

The genetics of Ewing sarcoma development remain obscure. The incidence of Ewing sarcoma is ten-fold less in Africans as compared to Europeans, irrespective of geographic location, suggesting population-specific genetic influences. Since GGAA-containing microsatellites within key target genes are necessary for Ewing sarcoma-specific EWS/FLI DNA binding and gene activation, and gene expression is positively...

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Identifiers

PMID: 22749036
DOI: 10.1016/j.cancergen.2012.04.004
PMCID: PMC3389350

Genes

CAV1

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EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.PMID 22749036Read ↗

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