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Article

In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells

5 Aug 2014

Abstract excerpt

BACKGROUND: The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) has revealed a number of unexpected beneficial effects, including a reduction in cancer risk. METHODS: We investigated the direct anticancer effects of different statins approved for clinical use on human breast and brain cancer cells. We also explored the effects of statins on cancer cells using in silico...

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PMID: 25093497
DOI: 10.1038/bjc.2014.431

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