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Article

Mevalonate Pathway and Human Cancers.

Current molecular pharmacology - 1 Jan 2017

Bathaie Seyedeh Zahra, Ashrafi Mahboobeh, Azizian Mahshid, Tamanoi Fuyuhiko

Abstract excerpt

Mevalonate (MVA) is synthesized from 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) by HMG-CoA reductase (HMG-CoAR). MVA is further metabolized to farnesyl pyrophosphate (FPP), a precursor of cholesterol and sterols. FPP is also converted to geranylgeranyl pyrophosphate, and these lipids are used for post-translational modification of proteins that are involved in various aspects of tumor development and...

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PMID: 26758953
DOI: 10.2174/1874467209666160112123205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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