Article
Predominance of hepatitis C virus Q80K among NS3 baseline-resistance-associated amino acid variants in direct-antiviral-agent-naïve patients with chronic hepatitis: single-centre experience.
Archives of virology - 1 Nov 2015
Ruggiero Tina, Proietti Alex, Boglione Lucio, Milia Maria Grazia, Allice Tiziano, Burdino Elisa, Orofino Giancarlo, Bonora Stefano, Di Perri Giovanni, Ghisetti Valeria
Abstract excerpt
In the era of direct-acting antiviral agents (DAAs), hepatitis C virus (HCV) genotyping tests at baseline are controversial. The HCV NS3-Q80K polymorphism is associated with resistance to the recently approved NS3 inhibitor simeprevir (SMV) when combined with PEG-interferon and ribavirin (PEG-IFN/RBV) and alternative therapy should be considered for patients with baseline Q80K. The aim of this study was to...
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