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Article

IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist.

American journal of respiratory and critical care medicine - 1 May 2013

Meyer Nuala J, Feng Rui, Li Mingyao, Zhao Yang, Sheu Chau-Chyun, Tejera Paula, Gallop Robert, Bellamy Scarlett, Rushefski Melanie, Lanken Paul N, Aplenc Richard, O'Keefe Grant E, Wurfel Mark M, Christiani David C, Christie Jason D

Abstract excerpt

RATIONALE: Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of genetic susceptibility factors remains incomplete. OBJECTIVES: To identify genetic risk variants for ARDS using large scale genotyping. METHODS: A multistage genetic association study was conducted of three critically ill populations phenotyped for ARDS. Stage I, a trauma cohort study (n = 224), was...

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PMID: 23449693
DOI: 10.1164/rccm.201208-1501OC
PMCID: PMC3707367

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