Article

Genetic Rescue of a Lethal Wasting Mutation ( <i> Syb1 <sup>lew/lew</sup> </i> ) by Neuron-Specific Expression of ECFP-Syb2

2026-05-26

Abstract excerpt

Lethal-wasting (lew) is a spontaneous null mutation in the Syb1/Vamp1 gene encoding the vesicular SNARE protein synaptobrevin 1 (SYB1/VAMP1). Homozygous Syb1 lew/lew mice exhibit profound impairment in neuromuscular transmission and die around three weeks after birth. Pathogenic variants in human SYB1 are associated with a variety of disorders such as hereditary spastic ataxia and congenital myasthenic syndrome...

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Literature Corpus work: b82d8825-a536-5843-9ca1-ecd5b35b8836
DOI: 10.64898/2026.05.22.727260

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