Article
A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K).
Pigment cell & melanoma research - 1 Jul 2016
Chitsazan Arash, Ferguson Blake, Ram Ramesh, Mukhopadhyay Pamela, Handoko Herlina Y, Gabrielli Brian, Soyer Peter H, Morahan Grant, Walker Graeme J
Abstract excerpt
Congenital nevi develop before birth and sometimes cover large areas of the body. They are presumed to arise from the acquisition of a gene mutation in an embryonic melanocyte that becomes trapped in the dermis during development. Mice bearing the Cdk4(R24C) ::Tyr-NRAS(Q) (61K) transgenes develop congenital nevus-like lesions by post-natal day 10, from melanocytes escaping the confines of hair follicles. We...
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