Article
High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase.
Acta crystallographica. Section D, Biological crystallography - 1 Aug 2014
Perduca Massimiliano, Bovi Michele, Bertinelli Mattia, Bertini Edoardo, Destefanis Laura, Carrizo Maria E, Capaldi Stefano, Monaco Hugo L
Abstract excerpt
Lipocalin-type prostaglandin D synthase (L-PGDS) catalyzes the isomerization of the 9,11-endoperoxide group of PGH2 (prostaglandin H2) to produce PGD2 (prostaglandin D2) with 9-hydroxy and 11-keto groups. The product of the reaction, PGD2, is the precursor of several metabolites involved in many regulatory events. L-PGDS, the first member of the important lipocalin family to be recognized as an enzyme, is also...
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