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Article

Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase.

Biochemical and biophysical research communications - 10 Sept 2021

Shimamoto Shigeru, Nakagawa Yusuke, Hidaka Yuji, Maruno Takahiro, Kobayashi Yuji, Kawahara Kazuki, Yoshida Takuya, Ohkubo Tadayasu, Aritake Kosuke, Kaushik Mahesh K, Urade Yoshihiro

Abstract excerpt

Prostaglandin D2 (PGD2), an endogenous somnogen, is a unique PG that is secreted into the cerebrospinal fluid. PGD2 is a relatively fragile molecule and should be transported to receptors localized in the basal forebrain without degradation. However, it remains unclear how PGD2 is stably carried to such remote receptors. Here, we demonstrate that the PGD2-synthesizing enzyme, Lipocalin-type prostaglandin D...

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Identifiers

PMID: 34237429
DOI: 10.1016/j.bbrc.2021.06.092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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