Article
NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity.
The Journal of biological chemistry - 26 Oct 2007
Shimamoto Shigeru, Yoshida Takuya, Inui Takashi, Gohda Keigo, Kobayashi Yuji, Fujimori Ko, Tsurumura Toshiharu, Aritake Kosuke, Urade Yoshihiro, Ohkubo Tadayasu
Abstract excerpt
Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) catalyzes the isomerization of PGH(2), a common precursor of various prostanoids, to produce PGD(2), an endogenous somnogen and nociceptive modulator, in the brain. L-PGDS is a member of the lipocalin superfamily and binds lipophilic substances, such as retinoids and bile pigments, suggesting that L-PGDS is a dual functional protein acting as a...
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