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Article

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells.

PloS one - 1 Jan 2014

Dago Angel E, Stepansky Asya, Carlsson Anders, Luttgen Madelyn, Kendall Jude, Baslan Timour, Kolatkar Anand, Wigler Michael, Bethel Kelly, Gross Mitchell E, Hicks James, Kuhn Peter

Abstract excerpt

Timely characterization of a cancer's evolution is required to predict treatment efficacy and to detect resistance early. High content analysis of single Circulating Tumor Cells (CTCs) enables sequential characterization of genotypic, morphometric and protein expression alterations in real time over the course of cancer treatment. This concept was investigated in a patient with castrate-resistant prostate cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25084170
DOI: 10.1371/journal.pone.0101777
PMCID: PMC4118839

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MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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