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Article

Clinical and genomic insights into circulating tumor DNA-based alterations across the spectrum of metastatic hormone-sensitive and castrate-resistant prostate cancer.

EBioMedicine - 1 Apr 2020

Kohli Manish, Tan Winston, Zheng Tiantian, Wang Amy, Montesinos Carlos, Wong Calven, Du Pan, Jia Shidong, Yadav Siddhartha, Horvath Lisa G, Mahon Kate L, Kwan Edmond M, Fettke Heidi, Yu Jianjun, Azad Arun A

Abstract excerpt

BACKGROUND: Metastatic prostate cancer is a clonally heterogeneous disease state characterized by progressive somatic perturbations. The aim of this study was to identify cell free DNA- (cfDNA-) based alterations and their associations with outcomes in progressive metastatic prostate cancer. METHODS: In this longitudinal prospective cohort study plasma cfDNA/circulating tumor DNA (ctDNA) was analyzed before,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32268276
DOI: 10.1016/j.ebiom.2020.102728
PMCID: PMC7186589

Genes

AR
APC
ATM
BRCA1
BRCA2
CHEK2
RB1
TP53

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