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CD133-enriched Xeno-Free human embryonic-derived neural stem cells expand rapidly in culture and do not form teratomas in immunodeficient mice.

Stem cell research - 1 Sept 2014

Haus Daniel L, Nguyen Hal X, Gold Eric M, Kamei Noriko, Perez Harvey, Moore Harry D, Anderson Aileen J, Cummings Brian J

Abstract excerpt

Common methods for the generation of human embryonic-derived neural stem cells (hNSCs) result in cells with potentially compromised safety profiles due to maintenance of cells in conditions containing non-human proteins (e.g. in bovine serum or on mouse fibroblast feeders). Additionally, sufficient expansion of resulting hNSCs for scaling out or up in a clinically relevant time frame has proven to be difficult....

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Identifiers

PMID: 25082219
DOI: 10.1016/j.scr.2014.06.008
PMCID: PMC5675021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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