Article
Genetic variants in genes of tricarboxylic acid cycle key enzymes predict postsurgical overall survival of patients with hepatocellular carcinoma.
Annals of surgical oncology - 1 Dec 2014
Du Xiaohong, Wan Shaogui, Chen Yibing, Qu Ping, Huang Xiaojun, Yu Xiaohe, Yang Hushan, Zhang Yiguan, Xing Jinliang
Abstract excerpt
BACKGROUND: Metabolic reprogramming is a hallmark of cancer, including the alterations of activity and expression in tricarboxylic acid (TCA) cycle key enzymes. However, the significance of single nucleotide polymorphisms (SNPs) in genes encoding these key enzymes has not been investigated in hepatocellular carcinoma (HCC). METHODS: In this study, 17 SNPs in seven genes encoding three TCA cycle enzyme families...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.