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Article

Polymorphisms in Genes of Tricarboxylic Acid Cycle Key Enzymes Are Associated with Early Recurrence of Hepatocellular Carcinoma.

PloS one - 1 Jan 2015

Wan Shaogui, Wu Yousheng, Zhou Xingchun, Chen Yibing, An Jiaze, Yu Xiaohe, Zhang Huiqing, Yang Hushan, Xing Jinliang

Abstract excerpt

Alterations of activity and expression in tricarboxylic acid (TCA) cycle key enzymes have been indicated in several malignancies, including hepatocellular carcinoma (HCC). They play an important role in the progression of cancer. However, the impact of single nucleotide polymorphisms (SNPs) in genes encoding these key enzymes on the recurrence of HCC has not been investigated. In this study, we genotyped 17 SNPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25894340
DOI: 10.1371/journal.pone.0124471
PMCID: PMC4404327

Genes

SDHD
IDH2
SDHC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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