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Article

Molecular Features of Gastrointestinal Stromal Tumors: A Single Referral Cancer Center Experience.

Anticancer research - 1 Jun 2026

Zupa Angela, Vita Giulia, Tartarone Alfredo, Omer Ludmila Carmen, Calice Giovanni, Improta Giuseppina

Abstract excerpt

BACKGROUND/AIM: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract. They frequently harbor mutations in KIT proto-oncogene, receptor tyrosine kinase (KIT) (70-80%) and platelet-derived growth factor receptor alpha (PDGFRA) (10-15%) genes, responding effectively to tyrosine kinase inhibitors (TKIs). Accurate genotyping is crucial for diagnosis and therapeutic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42203307
DOI: 10.21873/anticanres.18180

Genes

KIT
PDGFRA

Variants

Provenance

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