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Article

Kinase genotype analysis of gastric gastrointestinal stromal tumor cytology samples using targeted next-generation sequencing.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jan 2015

Gleeson Ferga C, Kipp Benjamin R, Kerr Sarah E, Voss Jesse S, Graham Rondell P, Campion Michael B, Minot Douglas M, Tu Zheng J, Klee Eric W, Lazaridis Konstantinos N, Henry Michael R, Levy Michael J

Abstract excerpt

Gastric gastrointestinal stromal tumors (GISTs) usually contain the mast/stem cell growth factor receptor Kit gene (KIT) or platelet-derived growth factor receptor A (PDGFRA) mutations that can be targeted by, or mediate resistance to, imatinib. Diagnostic material often is obtained by endoscopic ultrasound-guided fine-needle aspiration, which often is unsuitable for molecular analysis. We investigated whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-kit

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Source

Identifiers

PMID: 24997326
DOI: 10.1016/j.cgh.2014.06.024

Genes

KIT
PDGFRA
BRAF
FGFR3
KRAS
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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