Article
Influence of Polymorphism (-G308A) TNF-α on the Periportal Fibrosis Regression of Schistosomiasis After Specific Treatment.
Genetic testing and molecular biomarkers - 1 Nov 2015
Oliveira Juliana B, Silva Paula C V, Vasconcelos Leticia M, Gomes Adriana V, Coêlho Maria Rosãngela C D, Cahu Georgea G O M, Muniz Maria Tereza Cartaxo, Domingues Ana Lúcia C
Abstract excerpt
AIMS: Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine and important mediator of severity for periportal fibrosis (PPF). We hypothesized that the (-G380A) polymorphism in the TNF-α gene is associated with regression of PPF after treatment for schistosomiasis mansoni. METHODS: This is a retrospective cohort study, involving 124 Brazilian patients infected with Schistosoma mansoni, who were...
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