Article
IFN-gamma polymorphisms (IFN-gamma +2109 and IFN-gamma +3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni).
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2003
Chevillard Christophe, Moukoko Carole Eboumbou, Elwali Nasr-Eldin M A, Bream Jay H, Kouriba Bourema, Argiro Laurent, Rahoud Siddig, Mergani Adil, Henri Sandrine, Gaudart Jean, Mohamed-Ali Qurashi, Young Howard A, Dessein Alain J
Abstract excerpt
Schistosome infection is a major public health concern affecting millions of people living in tropical regions of Africa, Asia, and South America. Schistosomes cause mild clinical symptoms in most subjects, whereas a small proportion of individuals presents severe clinical disease (as periportal fibrosis (PPF)) that may lead to death. Severe PPF results from an abnormal deposition of extracellular matrix proteins...
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