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Influence of metalloproteinase-3 (-1171 5A>6A) polymorphism on periportal fibrosis in patients with schistosomiasis mansoni, Pernambuco, Brazil.

Acta tropica - 1 Dec 2024

Silva Thaysa Carolina Gonçalves, Silva Paula Carolina Valença, de Lima Elker Lene Santos, Muniz Maria Tereza Cartaxo, Lopes Edmundo Pessoa, Domingues Ana Lúcia Coutinho

Abstract excerpt

In schistosomiasis mansoni (SM), periportal fibrosis (PPF) arises due to an inflammatory response exacerbated by parasite eggs in the intrahepatic portal space, culminating in the deposition of collagen and extracellular matrix proteins. This fibrosis results from a remodeling process of the extracellular matrix, in which metalloproteinases play a significant role. The study evaluated the association between...

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PMID: 39489411
DOI: 10.1016/j.actatropica.2024.107450

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