Article
Influence of a TNF-α Polymorphism on the Severity of Schistosomiasis Periportal Fibrosis in the Northeast of Brazil.
Genetic testing and molecular biomarkers - 1 Nov 2017
Silva Paula Carolina Valença, Gomes Adriana Vieira, de Britto Lidiane Régia Pereira Braga, de Lima Elker Lene Santos, da Silva Jamile Luciana, Montenegro Silvia Maria Lucena, Muniz Maria Tereza Cartaxo, Domingues Ana Lúcia Coutinho
Abstract excerpt
AIMS: The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) is an essential component in the host immune response to infection, and it has been reported to be an important mediator in severe periportal fibrosis (PPF). We hypothesized that the (-G308A) polymorphism of the TNF-α gene is associated with the severity of PPF and that these polymorphisms influence TNF-α expression. METHODS: In this...
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