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Article

Combined Effects of the Structural Heterogeneity and Dynamics of Flaviviruses on Antibody Recognition

31 Jul 2014

Abstract excerpt

Flaviviruses are thought to sample an ensemble of structures at equilibrium. One consequence of a structurally dynamic virion is the observed time-dependent increases in neutralization sensitivity that can occur after prolonged incubation with antibody. Differences in how virus strains "breathe" may affect epitope exposure and contribute to the underlying mechanisms of strain-dependent neutralization sensitivity....

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PMID: 25078693
DOI: 10.1128/jvi.01140-14

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