Article

Genetically Engineered DENV Produces Antigenically Distinct Mature Particles

2021-04-08

Abstract excerpt

Maturation of Dengue viruses (DENV) alters the structure, immunity and infectivity of the virion and highly mature particles represent the dominant form in vivo . The production of highly mature virions principally relies on the structure and function of the viral premature protein (prM) and its cleavage by the host protease furin. We developed a reliable clonal cell line which produces single-round mature DENVs...

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Literature Corpus work: cf8e3d32-4be7-5532-8673-88d6a2ce49d7
DOI: 10.1101/2021.04.06.438747

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