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Article

RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology

6 Feb 2020

Abstract excerpt

RasGRP2 is calcium and diacylglycerol-regulated guanine nucleotide exchange factor I that activates Rap1, which is an essential signaling-knot in "inside-out" αIIbβ3 integrin activation in platelets. Inherited platelet function disorder caused by variants of RASGRP2 represents a new congenital bleeding disorder referred to as platelet-type bleeding disorder-18 (BDPLT18). We review here the structure of RasGRP2...

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PMID: 32041177
DOI: 10.3390/ijms21031075

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