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Article

GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.

eLife - 29 Jul 2014

Morgan-Smith Meghan, Wu Yaohong, Zhu Xiaoqin, Pringle Julia, Snider William D

Abstract excerpt

GSK-3 is an essential mediator of several signaling pathways that regulate cortical development. We therefore created conditional mouse mutants lacking both GSK-3α and GSK-3β in newly born cortical excitatory neurons. Gsk3-deleted neurons expressing upper layer markers exhibited striking migration failure in all areas of the cortex. Radial migration in hippocampus was similarly affected. In contrast, tangential...

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PMID: 25073924
DOI: 10.7554/eLife.02663
PMCID: PMC4109311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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