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Article

Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development.

Nature communications - 24 May 2021

Morandell Jasmin, Schwarz Lena A, Basilico Bernadette, Tasciyan Saren, Dimchev Georgi, Nicolas Armel, Sommer Christoph, Kreuzinger Caroline, Dotter Christoph P, Knaus Lisa S, Dobler Zoe, Cacci Emanuele, Schur Florian K M, Danzl Johann G, Novarino Gaia

Abstract excerpt

De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). In mouse, constitutive Cul3 haploinsufficiency leads to motor coordination deficits as well as ASD-relevant social and cognitive impairments. However, induction of Cul3 haploinsufficiency later in life does not lead to ASD-relevant behaviors, pointing to an important role of Cul3 during...

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Identifiers

PMID: 34031387
DOI: 10.1038/s41467-021-23123-x
PMCID: PMC8144225

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