Article
Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice.
Brain structure & function - 1 Apr 2017
Martinez-Garay Isabel, Guidi Luiz G, Holloway Zoe G, Bailey Melissa A G, Lyngholm Daniel, Schneider Tomasz, Donnison Timothy, Butt Simon J B, Monaco Anthony P, Molnár Zoltán, Velayos-Baeza Antonio
Abstract excerpt
Developmental dyslexia is a common disorder with a strong genetic component, but the underlying molecular mechanisms are still unknown. Several candidate dyslexia-susceptibility genes, including KIAA0319, DYX1C1, and DCDC2, have been identified in humans. RNA interference experiments targeting these genes in rat embryos have shown impairments in neuronal migration, suggesting that defects in radial cortical...
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