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SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

29 Jul 2014

Abstract excerpt

BACKGROUND: SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recently SIRT2 was revealed to play an important role in inflammation, directly binding, deacetylating, and inhibiting the p65 subunit of NF-κB. METHODS: A Sirt2...

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PMID: 25072851
DOI: 10.1371/journal.pone.0103573

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