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Article

Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells

19 Nov 2018

Abstract excerpt

Salmonella being a successful pathogen, employs a plethora of immune evasion mechanisms.This contributes to pathogenesis, persistence and also limits the efficacy of available treatment.All these contributing factors call upon for new drug targets against Salmonella.For the first time, we have demonstrated that Salmonella upregulates sirtuin 2 (SIRT2), an NAD + dependent deacetylase in dendritic cells (DC).SIRT2...

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PMID: 30452468
DOI: 10.1371/journal.ppat.1007437

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