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Article

SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation

1 Jan 2020

Abstract excerpt

BACKGROUND AND AIMS: Intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD). We investigated the role of Sirtuin 2 (SIRT2), a NAD-dependent protein deacetylase, in intestinal epithelial cell (IEC) proliferation and differentiation and the mechanism by which SIRT2...

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PMID: 31954883
DOI: 10.1016/j.jcmgh.2020.01.004

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