Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Committed Tc17 cells are phenotypically and functionally resistant to the effects of IL-27.

European journal of immunology - 1 Oct 2014

El-Behi Mohamed, Dai Hong, Magalhaes Joao G, Hwang Daniel, Zhang Guang-Xian, Rostami Abdolmohamad, Ciric Bogoljub

Abstract excerpt

IL-17-secreting CD8(+) T cells (Tc17 cells) have been implicated in immunity to infections, cancer, and autoimmune diseases. Thus far, studies on Tc17 cells have primarily investigated their development from naïve precursors, while the biology of committed Tc17 cells has been less characterized, in particular during the effector phase of immune responses. IL-27 is an important regulator of inflammation through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Flow Cytometry

Share to Interleukin-17

Share to Mice, Transgenic

Share to Real-Time Polymerase Chain Reaction

Share to T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 25070084
DOI: 10.1002/eji.201344360
PMCID: PMC8686168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Committed Tc17 cells are phenotypically and functionally resistant to the effects of IL-27.PMID 25070084Read ↗

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.Semantic proximity Read ↗

Development and function of interleukin 17-producing γδ T cells.Semantic proximity Read ↗

Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases.Semantic proximity Read ↗

Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T CellsSemantic proximity Read ↗

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.Semantic proximity Read ↗

Runx1 and Runx3 Are Involved in the Generation and Function of Highly Suppressive IL-17-Producing T Regulatory CellsSemantic proximity Read ↗

IL-27 maintains cytotoxic Ly6C <sup>+</sup> γδ T cells that arise from immature precursorsSemantic proximity Read ↗

Regulation and function of proinflammatory TH17 cells.Semantic proximity Read ↗

Th17 and Treg cells, two new lymphocyte subpopulations with a key role in the immune response against infection.Semantic proximity Read ↗

Recently discovered T cell subsets cannot keep their commitments.Semantic proximity Read ↗

Genes associated with T helper 17 cell differentiation and functionSemantic proximity Read ↗

The Yin and Yang of Type 1 Regulatory T Cells: From Discovery to Clinical Application.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.